Reversible acetylcholinesterase inhibitors are used as first-line treatment for myasthenia gravis (MG).
They improve symptoms by increasing concentration of acetylcholine at the neuromuscular junction and stimulating nicotinic receptors. Serious bradyarrhythmias can occur from muscarinic stimulation in heart, which in rare cases may progress to asystole (Flat Lining on ECG monitor).
